Moxi Z

Mini Automated Cell Counter Kit Moxi Z is the only automated cell counter that combines the Coulter Principle typically used in high-end cell counters with a patented thin-film sensor technology to allow for highly accurate.

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Description

Description

Improve downstream results with better quality control.

Moxi Z is the only automated cell counter that combines the Coulter Principle typically used in high-end cell counters with a patented thin-film sensor technology to allow for highly accurate (> 95%) and repeatable particle counting and sizing for a broad range of cell types – from mammalian cells to cells as small as wine yeast and more. Since today’s workflows demand accurate quality control of samples, determining cell counts precisely has a significant impact on outcomes and downstream costs.

Produce repeatable cell counts with >95% accuracy in just 8 seconds.

This ultra-small instrument uses patented microfluidic thin-film cassettes that enable automatic load and measure operation. The resulting single-cell volumetric measurements are completely technique-independent. It provides the ideal alternative to the tedious manual counting associated with cytometers, or the inaccurate results associated with image-based automated cell counters (typical accuracies of 75-80%).

Assess cell culture health without reagents or dyes.

Moxi Z also automatically reports a unique cell health assessment index – MPI (Moxi Population Index) – without the need for reagents or dyes.MPI is a ratio of the cell population of interest relative to the entire particle distribution in that sample, factoring in dead cells that have shrunken or broken apart as well as other debris and contaminants in the sample. For monodisperse mammalian cultures, this is closely correlated to the overall health of the sample.In the case of mixed cell populations, it provides an assessment of the relative fraction of the largest-sized population in the sample. Unlike staining-based viability methods that focus on the uptake by dead cells and do not account for contaminants and other debris, MPI provides insight into the primary population of interest (based on size) and its relationship to ALL other particles in the sample.

Measure the smallest cells at very high concentrations.

Using the new Type S cassette, you can now accurately measure the smallest cells of any automated cell counter (down to 3um average diameter) at concentrations of up to 2.5e+6/ml. This means the new Type S cassette can measure Yeast (including wine yeast) and non-spherical particles down to 14 fL in volume.

  • Results in just 8 seconds
  • Ultra-small and ultra-easy to use (no manual counting, no focusing of any kind)
  •  Complete, high-resolution cell size/count histogram
  • Handles “de-aggregation” and coincidence events
  • Post-processing/analysis of count distributions with user-adjustable regions/gates
  • Assess cell health (MPI) without the need for reagents like Trypan blue
Specifications

Specifications

 

ID MXZ001
Included Accessories Instrument Only
AC Power Type 110 VAC
Applications Cell Counting | Cell Size | Cell Health
Average Cell Diameter Range 4 – 25 microns Type M|3 – 20 microns Type S
Battery Type Rechargeable 3.7 V, 4400 mAh lithium ion
Cassette Types Type M |Type S
CE Certification Yes
Cell Particle Concentration Range 3,000 – 500,000 cells/mL Type M|3,000 – 1,750,000 cells/mL Type S
Cell Types Tested HEK-293|HeLa|PC12|CD3+T|CHO-K1|Cos-7|HepG2|Hybridoma|Jurkat E6-1|K562|MCF7|Mesenchymal SC | Monocyte | Mouse ESC| NIH 3T3| PBMC (cultured)|Red Blood Cells (RBC)|L5178y| C.albicans (Yeast)| S. cerevisiae Vin 13 (Yeast)|S. cerevisiae X5 (Yeast)|Wine Yeast (natural fermentaion)| S.cerevisiae (Baker’s Yeast | Safale US-05 Yeast
Compatible Instruments MOXI Z
Data Output Formats .csv format (Orflo MoxiChart or Microsoft Excel)
In British Units 1.5 lbs
Intended Use Statement For Research Use Only. Product is not for use in diagnostic procedures
Measurable Dynamic Range 4- 34 microns Type M|3 -26 microns Type S
Measurement Time 15 seconds Type S|10 seconds Type M
MPI Cell Health Ratio Yes
Number of Detection Channels Flow parameters 1
Overall Dimensions 7.6 L x 4.3 W x 2.8 H (in)
Particle Size Detection Method Impedimetric (Coulter Principle)
Platform No
Pre-Programmed Tests None
Sample Type Mammalian Cells|Large Yeast|Large Algae|Protozoa Type M/ Mammalian Cells|Most Yeast|Small Algae|Small Protozoa Type S
Sample Volume 75 µL
Supported Connectivity USB on-the-go; PC or Mac compatible; requires Windows XP, Windows Vista, Windows 7, or Mac OS X operating system
Useable Cell Volume 34 – 20,580 fL Type M|14 – 4,200 fL Type S
Weight 0.68 kg
Cassettes

Cassettes

Higher Performance & Simplicity in One Disposable Cassette.

Moxi Z’s unique, patent-protected thin-film cell count cassettes provide highly accurate, repeatable cell counts and cell size analysis in under 8 seconds (15 seconds for Type S cassette). Inspired by the gold-standard Coulter Principle used in high-end counting systems worldwide, the Moxi cassette flows thousands of cells per test through a cell sensing zone to accurately capture the impedance-based volumetric measurement of each individual cell in the sample. Impedance-based cell counting of individual cells is proven to be over 95% accurate versus 75% accuracy with image-based cell counting methods.

No system contamination and integrated pre-filter for clogging prevention.

Moxi cassettes are designed with a unique “cell sieve” to minimize cell clumping and clogging. In addition, Moxi cassettes contain 100% of your sample within the cassette body, eliminating the possibility of system contamination and sterilization. Cassettes are simply and easily discarded when testing is finished. 

Moxi Z Type S Cassettes

The Type S cassette is ideal for accurately measuring most yeast and other particles as small as 3 microns and up to 20 microns in average diameter including some algae and protozoa. Since the technology is based on a volumetric measurement, non-spherical particles (14 – 4,200 fL) can also be measured accurately.

  • Moxi Z Type S Pack (3 packs of 25 Cassettes)
  • Moxi Z Type S Box (250 Cassettes)

Moxi Z Type M Cassettes

The Type M cassette is ideal for accurately measuring mammalian cells or other particles 4-25 microns in average diameter. Since the technology is based on a volumetric measurement, non-spherical particles (34-8,180 fL) can also be measured accurately.

  • Moxi Z Type M Pack (3 packs of 25 Cassettes)
  • Moxi Z Type M Box (250 Cassettes)
Assay Kits & Reagents

Assay Kits & Reagents

Assay Kits

1. Moxi Cyte Viability (PI)

Propidium Iodide (PI) is a fluorescent dye that is impermeable to healthy cells. When cells die, their membranes become permeable. PI enters the cell, binds to the DNA, and increases fluorescence 50x +. This strong signal for measuring cell viability has made PI the gold-standard approach used in flow cell viability assessment.

2. Orflo Moxi Cyte Nucleated Counts (AO) / Viability (PI) Reagent

The MXA069 reagent is designed for the identification and enumeration of all nucleated cells (Acridine Orange, membrane permeable) in a sample, while simultaneously assessing viability (Propidium Iodide, cell impermeant).

3. Orflo Early Stage Apoptosis Kit (FITC Annexin V / PI)

The MXA701 Early Stage Apoptosis kit is designed to identify early-stage apoptosis in cells by monitoring the phosphatidylserine exposure on the exterior plasma membrane, a hallmark of apoptosis. PI is added to further discriminate the necrotic cells.

 

Reagents

1. Moxi Z System Check Beads

Utilize the Moxi Z System Check Beads to periodically check count accuracy. You must flow the Moxi Z System Check Bead protocol to ensure accurate results

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